McMaster University Observational Study shows Significant Changes in Health Outcomes with Dynamic Neural Retraining System™️(DNRS)


‘Neuroplasticity-based treatment for fibromyalgia, chronic fatigue and multiple chemical sensitivity: feasibility and outcomes’ Guenter D, et al. (2019)


The graphs are from a presentation given by lead researcher, Dr. Dale Guenter, at the North American Primary Care Research Group Conference, in Toronto, Canada in November 2019.

Researchers at McMaster University followed 102 people who attended the 5-day DNRS Interactive Training Seminar for one year in 2016 and 2017. They asked them to complete 6 standardized health surveys prior to attending the program along with 3, 6 and 12-month follow up surveys to track changes in symptoms.

View an 18 minute synopsis of the research study by head researcher Dr. Dale Guenter here.


The surveys measured the following:

  • Quality of Life (SF36)
  • Fatigue Severity Scale (FSS)
  • Symptom Impact Questionnaire (SIQR)
  • Quick Environmental Exposure and Sensitivity Inventory (QEESI)
  • Anxiety (GAD-7)
  • Depression (PHQ-9)

People who attended the program reported suffering from numerous and often overlapping conditions – here are the top 14.

Adrenal Insufficiency
Chronic Fatigue Syndrome
Chronic Inflammatory Response Syndrome (CIRS)
Chronic Pain

Food Allergies/ Sensitivities
Irritable Bowel Syndrome
Lyme Disease
Migraines/ Headaches
Multiple Chemical Sensitivity
Neurological disorders
Post-Traumatic Stress Disorder


Research Question: Does DNRS make a difference in people’s lives?

According to this study, quality of life and function improved dramatically using DNRS over a period of twelve months.

To answer this question, they used the Quality of Life survey (SF36) with baseline measurements and follow up measurements at 3,6 and 12 months post DNRS.

The Quality of Life survey (SF36) measured eight life components.

Each of the eight components are listed on the graph above; each with its own color and acronym.

  1. Blue represents physical function (or PF)
  2. Brown represents mental health (or MH)
  3. Green represents social function (or SF)
  4. Gray represents bodily pain (or BP)
  5. Yellow represents general health (or GH)
  6. Dark blue represents emotional function (or RE)
  7. Light Blue represents vitality (or VT)
  8. Orange represents physical activities at work or home (or RP)
  • In this survey, the average healthy Canadian comparison scores ranged between 70-90%
  • You can see that all 8 quality of life and function measures increased over a 12-month time span, approaching and/or meeting the healthy Canadian average.

Research Question: Does DNRS Have an Effect on People’s Symptoms?

To answer this question, we will want to look at the rest of the surveys used to assess these areas:

  • Fibromyalgia
  • Fatigue
  • Anxiety
  • Depression
  • Multiple Chemical Intolerance


  • You will notice that each pair of bars represents one of the specific surveys. Each survey measures whether a person meets the criteria for fibromyalgia, chronic fatigue, anxiety, depression and multiple chemical sensitivities (or chemical intolerance).
  • The first bar represents the percentage of people meeting the criteria for the condition before participating in DNRS.
  • The second bar represents the percentage of people meeting the criteria for the condition 12 months after participating in DNRS.

Percent of participants with score above diagnostic cutoff at 0 and 12 months


  • 76.9 Before DNRS
  • 26.7 After DNRS

Chronic Fatigue

  • 71.7 Before DNRS
  • 28.6 After DNRS


  • 48.4 Before DNRS
  • 6.5 After DNRS


  • 48.4 Before DNRS
  • 12.9 After DNRS


  • 38.9 Before DNRS
  • 6.3 After DNRS
Fibromyalgia 76.9 before DNRS 26.7 after DNRS
Chronic Fatigue 71.7 before DNRS 28.6 after DNRS
Anxiety 48.4 before DNRS 6.5 after DNRS
Depression 47.3 before DNRS 12.9 after DNRS
Multiple Chemical Sensitivities 38.9 before DNRS 6.3 after DNRS


  • Let’s look at the high-level summary of findings…
  • Fibromyalgia and chronic fatigue were the most common conditions among participants
  • A significant improvement was seen in the first three months following DNRS
  • After 12 months on average all categories improved
  • Statistically, there is less than 1 in 1000 likelihood that these changes happened by chance

This study has been submitted for publication but not yet published.

Appendix for McMaster Research
1. Yunus MB. Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes. InSeminars in arthritis and rheumatism 2007 Jun 1 (Vol. 36, No. 6, pp. 339-356). WB Saunders.
2. Kindler LL, Bennett RM, Jones KD. Central sensitivity syndromes: mounting pathophysiologic evidence to link fibromyalgia with other common chronic pain disorders. Pain management nursing. 2011 Mar 1;12(1):15-24.
3. Hauge CR, Rasmussen A, Piet J, Bonde JP, Jensen C, Sumbundu A, Skovbjerg S. Mindfulness-based cognitive therapy (MBCT) for multiple chemical sensitivity (MCS): Results from a randomized controlled trial with 1 year follow-up. Journal of psychosomatic research. 2015 Dec 1;79(6):628-34.

4. Tran MT, Skovbjerg S, Arendt-Nielsen L, Christensen KB, Elberling J. A randomised, placebo-controlled trial of transcranial pulsed electromagnetic fields in patients with multiple chemical sensitivity. Acta neuropsychiatrica. 2017 Oct;29(5):267-77.

5. Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, Russell IJ. Fibromyalgia syndrome in need of effective treatments. Journal of Pharmacology and Experimental Therapeutics. 2015 Nov 1;355(2):255-63.

6. Nüesch E, Häuser W, Bernardy K, Barth J, Jüni P. Comparative efficacy of pharmacological and non-pharmacological interventions in fibromyalgia syndrome: network meta-analysis. Annals of the Rheumatic Diseases. 2013 Jun 1;72(6):955-62.
7. Theadom A, Cropley M, Smith HE, Feigin VL, McPherson K. Mind and body therapy for fibromyalgia. Cochrane Database of Systematic Reviews. 2015(4)

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